γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors

γ1-Containing GABA-A Receptors Cluster at Synapses Where they Mediate Slower Synaptic Currents than γ2-Containing GABA-A Receptors

GABA-A receptors (GABAARs) are pentameric ligand-gated ion channels that are assembled mainly from α (α1–6), β (β1–3) and γ (γ1–3) subunits. Although GABAARs containing γ2L subunits mediate most of the inhibitory neurotransmission in the brain, significant expression of γ1 subunits is seen in the am...

Full description

Bibliographic Details
Main Authors: Christine L. Dixon, Pankaj Sah, Angelo Keramidas, Joseph W. Lynch, Nela Durisic
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
γ1-subunit clustering
inhibitory neurotransmission
synapse
spillover
IPSC
artificial synapse
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00178/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00178/full

Similar Items