Strong and long-lasting antinociceptive and anti-inflammatory conjugate of naturally occurring oleanolic acid and aspirin

Strong and long-lasting antinociceptive and anti-inflammatory conjugate of naturally occurring oleanolic acid and aspirin

The conjugate 8 was obtained as a result of condensation of 3-hydroxyiminooleanolic acid morfolide (7) and aspirin in dioxane. Analgesic effect of OAO-ASA (8) for the range of doses 0.3 – 300.0 mg/kg (p.o.) was performed in mice using a hot plate test. Anti-inflammatory activity was assessed on carr...

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Bibliographic Details
Main Authors: Barbara Bednarczyk-Cwynar, Natalia Wachowiak, Michal Szulc, Ewa Kaminska, Anna Bogacz, Joanna Bartkowiak-Wieczorek, Lucjusz Zaprutko, Przemyslaw Lukasz Mikolajczak
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-07-01
Series:Frontiers in Pharmacology
Subjects:
Oleanolic Acid
Triterpenes
anti-inflammatory activity
analgesic activity
mRNA expression
acetylsalicylic acid
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00202/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00202/full

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