The Expression of TRIM6 Activates the mTORC1 Pathway by Regulating the Ubiquitination of TSC1-TSC2 to Promote Renal Fibrosis

The Expression of TRIM6 Activates the mTORC1 Pathway by Regulating the Ubiquitination of TSC1-TSC2 to Promote Renal Fibrosis

Renal fibrosis is considered as the final pathway of all types of kidney diseases, which can lead to the progressive loss of kidney functions and eventually renal failure. The mechanisms behind are diversified, in which the mammalian target of rapamycin (mTOR) pathway is one of the most important re...

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Bibliographic Details
Main Authors: Weiwei Liu, Yang Yi, Chuanfu Zhang, Baojuan Zhou, Lin Liao, Wenrui Liu, Jing Hu, Qiming Xu, Jie Chen, Jianrao Lu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TRIM6
angiotensin II
renal fibrosis
mTOR
TSC1
TSC2
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.616747/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.616747/full

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