Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome

Overexpression of mitochondrial oxodicarboxylate carrier (ODC1) preserves oxidative phosphorylation in a yeast model of Barth syndrome

Cardiolipin (CL) is a diglycerol phospholipid mostly found in mitochondria where it optimizes numerous processes, including oxidative phosphorylation (OXPHOS). To function properly, CL needs to be unsaturated, which requires the acyltransferase tafazzin. Loss-of-function mutations in this protein ar...

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Bibliographic Details
Main Authors: Maxence de Taffin de Tilques, Déborah Tribouillard-Tanvier, Emmanuel Tétaud, Eric Testet, Jean-Paul di Rago, Jean-Paul Lasserre
Format: Article
Language:English
Published: The Company of Biologists 2017-04-01
Series:Disease Models & Mechanisms
Subjects:
Human mitochondrial disease
Oxidative phosphorylation
Barth syndrome
Oxodicarboxylic acid transport
Cardiolipin remodeling
Tafazzin
Online Access:http://dmm.biologists.org/content/10/4/439

Internet

http://dmm.biologists.org/content/10/4/439

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