A non-invasive far-red light-induced split-Cre recombinase system for controllable genome engineering in mice

Current light-inducible Cre-loxP systems have minimal capacity for deep tissue penetration. Here, the authors present a far-red light-induced split Cre-loxP system for in vivo genome engineering.

Bibliographic Details
Main Authors: Jiali Wu, Meiyan Wang, Xueping Yang, Chengwei Yi, Jian Jiang, Yuanhuan Yu, Haifeng Ye
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17530-9