Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers

Endophilin A2 promotes HER2 internalization and sensitivity to trastuzumab-based therapy in HER2-positive breast cancers

Abstract Background Human epidermal growth factor receptor-2 (HER2) is amplified and a clinical target in a subset of human breast cancers with high rates of metastasis. Targeted therapies involving the antibody trastuzumab and trastuzumab-emtansine (T-DM1) have greatly improved outcomes for HER2-po...

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Bibliographic Details
Main Authors: Tomas Baldassarre, Peter Truesdell, Andrew W. Craig
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Breast Cancer Research
Subjects:
HER2 breast cancer
HER2 internalization
Trastuzumab
T-DM1
Endophilin
Online Access:http://link.springer.com/article/10.1186/s13058-017-0900-z

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http://link.springer.com/article/10.1186/s13058-017-0900-z

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