GM1 ganglioside prevents seizures, Na+,K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole

GM1 ganglioside prevents seizures, Na+,K+-ATPase activity inhibition and oxidative stress induced by glutaric acid and pentylenetetrazole

Monosialoganglioside (GM1) is a glycosphingolipid that protects against some neurological conditions, such as seizures and ischemia. Glutaric acidemia type I (GA-I) is an inherited disease characterized by striatal degeneration, seizures, and accumulation of glutaric acid (GA). In this study, we sho...

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Bibliographic Details
Main Authors: Michele Rechia Fighera, Luiz Fernando Freire Royes, Ana Flávia Furian, Mauro Schneider Oliveira, Natália Gindri Fiorenza, Roberto Frussa-Filho, João Carlos Petry, Rafael Correa Coelho, Carlos Fernando Mello
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Neurobiology of Disease
Subjects:
Seizure
EEG
Glutaric acid
Oxidative damage
GM1
Protein carbonylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106000040

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http://www.sciencedirect.com/science/article/pii/S0969996106000040

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