Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats

Mutations in Cytosine-5 tRNA Methyltransferases Impact Mobile Element Expression and Genome Stability at Specific DNA Repeats

Summary: The maintenance of eukaryotic genome stability is ensured by the interplay of transcriptional as well as post-transcriptional mechanisms that control recombination of repeat regions and the expression and mobility of transposable elements. We report here that mutations in two (cytosine-5) R...

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Bibliographic Details
Main Authors: Bianca Genenncher, Zeljko Durdevic, Katharina Hanna, Daniela Zinkl, Mehrpouya Balaghy Mobin, Nevcin Senturk, Bruno Da Silva, Carine Legrand, Clément Carré, Frank Lyko, Matthias Schaefer
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
transfer RNA
RNA modification
cytosine-5 RNA methylation
tRNA fragments
mobile elements
DNA repeats
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301104

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http://www.sciencedirect.com/science/article/pii/S2211124718301104

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