Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-κB-Bcl-2/Bax Axis

Doxycycline Protects Thymic Epithelial Cells from Mitomycin C-Mediated Apoptosis In Vitro via Trx2-NF-κB-Bcl-2/Bax Axis

Background/Aims: Age-associated and stress-induced involution of the thymus is accompanied by reduced numbers of thymic epithelial cells (TECs) and severe reduction in peripheral T cell repertoire specificities. These events seriously affect immune function, but the mechanisms involved are unclear....

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Bibliographic Details
Main Authors: Jun Wang, Ya Zhuo, Lei Yin, Hui Wang, Yanqiu Jiang, Xia Liu, Miaomiao Zhang, Fengyi Du, Sheng Xia, Qixiang Shao
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
Trx2
NF-κB
Thymic epithelial cell
Anti-apoptosis
Mitomycin C
Doxycycline
Online Access:http://www.karger.com/Article/FullText/438642

Internet

http://www.karger.com/Article/FullText/438642

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