Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer

Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer

<p>Abstract</p> <p>Background</p> <p>The α6β4 integrin is overexpressed in the basal subtype of breast cancer and plays an important role in tumor cell motility and invasion. EGFR is also overexpressed in the basal subtype of breast cancer, and crosstalk between α6β4 in...

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Bibliographic Details
Main Authors: Woodward Wendy A, Lu Xiaolin, Zhou Xiao, Gilcrease Michael Z, Hall Brian E, Morrissey Phillip J
Format: Article
Language:English
Published: BMC 2009-05-01
Series:Journal of Experimental & Clinical Cancer Research
Online Access:http://www.jeccr.com/content/28/1/67

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http://www.jeccr.com/content/28/1/67

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