The use of Ion Mobility Mass Spectrometry to probe Modulation of Function of p53 and of MDM2 by Small Molecule Inhibitors

The use of Ion Mobility Mass Spectrometry to probe Modulation of Function of p53 and of MDM2 by Small Molecule Inhibitors

Developing drug-like molecules to inhibit the interactions formed by disordered proteins is sought after but challenging due in part to the lack of solved structures from conformationally dynamic systems. Ion Mobility Mass Spectrometry (IM-MS) is well positioned to assess protein ligand interactions...

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Bibliographic Details
Main Authors: Eleanor Rose Dickinson, Ewa eJurneczko, Judith eNicholson, Ted eHupp, Joanna eZawacka-Pankau, Galina eSelivanova, Perdita Elizabeth Barran
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
p53
MDM2
Ion mobility mass spectrometry
Conformational Dynamics1
small molecule modulation.
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00039/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmolb.2015.00039/full

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