Analysis of Methylation Dynamics Reveals a Tissue-Specific, Age-Dependent Decline in 5-Methylcytosine Within the Genome of the Vertebrate Aging Model Nothobranchius furzeri

Analysis of Methylation Dynamics Reveals a Tissue-Specific, Age-Dependent Decline in 5-Methylcytosine Within the Genome of the Vertebrate Aging Model Nothobranchius furzeri

Erosion of the epigenetic DNA methylation landscape is a widely recognized hallmark of aging. Emerging advances in high throughput sequencing techniques, in particular DNA methylation data analysis, have resulted in the establishment of precise human and murine age prediction tools. In vertebrates,...

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Bibliographic Details
Main Authors: Gordin Zupkovitz, Julijan Kabiljo, Michael Kothmayer, Katharina Schlick, Christian Schöfer, Sabine Lagger, Oliver Pusch
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Molecular Biosciences
Subjects:
aging
epigenetics
DNA methylation
DNA hydroxymethylation
epigenetic aging clock
African turquoise killifish
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.627143/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.627143/full

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