Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.

Brain accumulation of the amyloid-β peptide (Aβ) and oxidative stress underlie neuronal dysfunction and memory loss in Alzheimer's disease (AD). Hexokinase (HK), a key glycolytic enzyme, plays important pro-survival roles, reducing mitochondrial reactive oxygen species (ROS) generation and prev...

Full description

Bibliographic Details
Main Authors: Leonardo M Saraiva, Gisele S Seixas da Silva, Antonio Galina, Wagner S da-Silva, William L Klein, Sérgio T Ferreira, Fernanda G De Felice
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-12-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3002973?pdf=render

Internet

http://europepmc.org/articles/PMC3002973?pdf=render

Similar Items