Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity

Discovery of New Pyrazolopyridine, Furopyridine, and Pyridine Derivatives as CDK2 Inhibitors: Design, Synthesis, Docking Studies, and Anti-Proliferative Activity

New pyridine, pyrazoloyridine, and furopyridine derivatives substituted with naphthyl and thienyl moieties were designed and synthesized starting from 6-(naphthalen-2-yl)-2-oxo-4-(thiophen-2-yl)-1,2-dihydropyridine-3-carbonitrile (<b>1</b>). The chloro, methoxy, cholroacetoxy, imidazolyl...

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Bibliographic Details
Main Authors: Adel A.-H. Abdel-Rahman, Amira K. F. Shaban, Ibrahim F. Nassar, Dina S. EL-Kady, Nasser S. M. Ismail, Samy F. Mahmoud, Hanem M. Awad, Wael A. El-Sayed
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Molecules
Subjects:
pyridine
imidazole
pyrazolo[3,4-b]pyridine
anticancer
HepG2
docking
Online Access:https://www.mdpi.com/1420-3049/26/13/3923

Internet

https://www.mdpi.com/1420-3049/26/13/3923

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