Regulation of T cell antitumor immune response by tumor induced metabolic stress

• Main Authors: Fanny Chalmin, Mélanie Bruchard, Frederique Vegran, Francois Ghiringhelli
• Format: Article
• Language: English
• Published: Shared Science Publishers OG 2018-11-01
• Series: Cell Stress
• Subjects: antitumor immmunity; metabolic stress; acidosis; hypoxia; amino acids; fatty acid; T cells
• Online Access: http://www.cell-stress.com/researcharticles/2019a-chalmin-cell-stress/
• ISSN: 2523-0204

Adaptive T cell immune response is essential for tumor growth control. The efficacy of immune checkpoint inhibitors is regulated by intratumoral immune response. The tumor microenvironment has a major role in adaptive immune response tuning. Tumor cells generate a particular metabolic environment in comparison to other tissues. Tumors are characterized by glycolysis, hypoxia, acidosis, amino acid depletion and fatty acid metabolism modification. Such metabolic changes promote tumor growth, impair immune response and lead to resistance to therapies. This review will detail how these modifications strongly affect CD8 and CD4 T cell functions and impact immunotherapy efficacy.