A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation

<p>Abstract</p> <p>Background</p> <p>Alterations in multiple cellular pathways contribute to the development of chronic neurodegeneration such as a sporadic Alzheimer's disease (AD). These, in turn, involve changes in gene expression, amongst which are genes regula...

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Bibliographic Details
Main Authors: Sikorska Marianna, Lei Joy X, Liu Qing, Liu Rugao
Format: Article
Language:English
Published: BMC 2008-02-01
Series:Molecular Neurodegeneration
Online Access:http://www.molecularneurodegeneration.com/content/3/1/4