Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models

Subcutaneous preconditioning increases invasion and metastatic dissemination in mouse colorectal cancer models

Mouse colorectal cancer (CRC) models generated by orthotopic microinjection of human CRC cell lines reproduce the pattern of lymphatic, haematological and transcoelomic spread but generate low metastatic efficiency. Our aim was to develop a new strategy that could increase the metastatic efficiency...

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Bibliographic Details
Main Authors: Patricia Alamo, Alberto Gallardo, Miguel A. Pavón, Isolda Casanova, Manuel Trias, Maria A. Mangues, Esther Vázquez, Antonio Villaverde, Ramon Mangues, Maria V. Céspedes
Format: Article
Language:English
Published: The Company of Biologists 2014-03-01
Series:Disease Models & Mechanisms
Subjects:
Collective invasion
Colorectal cancer model
Metastasis
Orthotopic injection
Single tumour cell
Subcutaneous preconditioning
Online Access:http://dmm.biologists.org/content/7/3/387

Internet

http://dmm.biologists.org/content/7/3/387

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