Blocking podoplanin suppresses growth and pulmonary metastasis of human malignant melanoma

Blocking podoplanin suppresses growth and pulmonary metastasis of human malignant melanoma

Abstract Background Podoplanin (PDPN), a transmembrane O-glycoprotein, is up-regulated in many tumors and is involved in tumor metastasis and malignant progression. In previous studies, we generated a functional blocking monoclonal antibody (mAb, SZ168) against the extracellular domain of human PDPN...

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Bibliographic Details
Main Authors: Mengqiao Xu, Xia Wang, Yanfang Pan, Xingpeng Zhao, Bin Yan, Changgeng Ruan, Lijun Xia, Yiming Zhao
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Cancer
Subjects:
Podoplanin
Antibody-based therapy
Malignant melanoma
Metastasis
Tumor growth
Online Access:http://link.springer.com/article/10.1186/s12885-019-5808-9

Internet

http://link.springer.com/article/10.1186/s12885-019-5808-9

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