Three-drug combination of lacosamide, phenobarbital and valproate exerts additive interaction in the tonic-clonic seizure model in mice

Three-drug combination of lacosamide, phenobarbital and valproate exerts additive interaction in the tonic-clonic seizure model in mice

Introduction Triple-therapy with antiepileptic drugs (AEDs) is usually prescribed for epilepsy patients, whose seizures are not fully controlled with standard medications. Although 25 various AEDs are currently licensed for treating epilepsy, no algorithms allowing for the proper combination of AEDs...

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Bibliographic Details
Main Authors: Maria Kondrat-Wróbel, Paweł Marzęda, Hubert Bojar, Paula Wróblewska-Łuczka, Justyna Kozińska, Marek Jankiewicz, Mateusz Kominek, Jarogniew J. Łuszczki
Format: Article
Language:English
Published: Institute of Rural Health 2020-09-01
Series:Journal of Pre-Clinical and Clinical Research
Subjects:
valproate
drug interactions
phenobarbital
isobolographic analysis
lacosamide
tonic-clonic seizures
Online Access:http://www.journalssystem.com/jpccr/Three-drug-combination-of-lacosamide-phenobarbital-and-valproate-exerts-additive,127377,0,2.html

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http://www.journalssystem.com/jpccr/Three-drug-combination-of-lacosamide-phenobarbital-and-valproate-exerts-additive,127377,0,2.html

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