The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene.

The GATA1-HS2 enhancer allows persistent and position-independent expression of a β-globin transgene.

Gene therapy of genetic diseases requires persistent and position-independent expression of a therapeutic transgene. Transcriptional enhancers binding chromatin-remodeling and modifying complexes may play a role in shielding transgenes from repressive chromatin effects. We tested the activity of the...

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Bibliographic Details
Main Authors: Annarita Miccio, Valentina Poletti, Francesca Tiboni, Claudia Rossi, Antonella Antonelli, Fulvio Mavilio, Giuliana Ferrari
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3229501?pdf=render

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http://europepmc.org/articles/PMC3229501?pdf=render

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