Ponatinib Induces Vascular Toxicity through the Notch-1 Signaling Pathway

Ponatinib Induces Vascular Toxicity through the Notch-1 Signaling Pathway

Ponatinib, a third-generation tyrosine kinase inhibitor (TKI), is the only approved TKI that is effective against T315I mutations in patients with chronic myeloid leukemia (CML). Specific activation of Notch signaling in CML cells by ponatinib can be considered as the “on-target effect&...

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Bibliographic Details
Main Authors: Rosalinda Madonna, Damiana Pieragostino, Maria Concetta Cufaro, Vanessa Doria, Piero Del Boccio, Martino Deidda, Sante Donato Pierdomenico, Christian Cadeddu Dessalvi, Raffaele De Caterina, Giuseppe Mercuro
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Journal of Clinical Medicine
Subjects:
tyrosine kinase inhibitors
ponatinib
vascular toxicity
notch-1
Online Access:https://www.mdpi.com/2077-0383/9/3/820

Internet

https://www.mdpi.com/2077-0383/9/3/820

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