Ultraviolet (UV) and Hydrogen Peroxide Activate Ceramide-ER Stress-AMPK Signaling Axis to Promote Retinal Pigment Epithelium (RPE) Cell Apoptosis

Ultraviolet (UV) and Hydrogen Peroxide Activate Ceramide-ER Stress-AMPK Signaling Axis to Promote Retinal Pigment Epithelium (RPE) Cell Apoptosis

Ultraviolet (UV) radiation and reactive oxygen species (ROS) impair the physiological functions of retinal pigment epithelium (RPE) cells by inducing cell apoptosis, which is the main cause of age-related macular degeneration (AMD). The mechanism by which UV/ROS induces RPE cell death is not fully a...

Full description

Bibliographic Details
Main Authors: Jin Yao, Hui-E Bi, Yi Sheng, Li-Bo Cheng, Ri-Le Wendu, Cheng-Hu Wang, Guo-Fan Cao, Qin Jiang
Format: Article
Language:English
Published: MDPI AG 2013-05-01
Series:International Journal of Molecular Sciences
Subjects:
age-related macular degeneration (AMD)
UV
ROS
RPE cell apoptosis
ceramide
ER stress and AMPK
Online Access:http://www.mdpi.com/1422-0067/14/5/10355

Internet

http://www.mdpi.com/1422-0067/14/5/10355

Similar Items