A two-stage microbial association mapping framework with advanced FDR control

Abstract Background In microbiome studies, it is important to detect taxa which are associated with pathological outcomes at the lowest definable taxonomic rank, such as genus or species. Traditionally, taxa at the target rank are tested for individual association, followed by the Benjamini-Hochberg...

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Bibliographic Details
Main Authors: Jiyuan Hu, Hyunwook Koh, Linchen He, Menghan Liu, Martin J. Blaser, Huilin Li
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Microbiome
Subjects:
Online Access:http://link.springer.com/article/10.1186/s40168-018-0517-1