Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

Antibody inhibition of contact factor XII reduces platelet deposition in a model of extracorporeal membrane oxygenator perfusion in nonhuman primates

Abstract Background The contact factor XII (FXII) activates upon contact with a variety of charged surfaces. Activated FXII (FXIIa) activates factor XI, which activates factor IX, resulting in thrombin generation, platelet activation, and fibrin formation. In both in vitro and in vivo rabbit models,...

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Bibliographic Details
Main Authors: Michael Wallisch, Christina U. Lorentz, Hari H. S. Lakshmanan, Jennifer Johnson, Marschelle R. Carris, Cristina Puy, David Gailani, Monica T. Hinds, Owen J. T. McCarty, András Gruber, Erik I. Tucker
Format: Article
Language:English
Published: Wiley 2020-02-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
blood platelet
extracorporeal membrane oxygenation
factor XII
hemostasis
thrombosis
Online Access:https://doi.org/10.1002/rth2.12309

Internet

https://doi.org/10.1002/rth2.12309

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