HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

HIF2A gain-of-function mutation modulates the stiffness of smooth muscle cells and compromises vascular mechanics

Summary: Heterozygous gain-of-function (GOF) mutations of hypoxia-inducible factor 2α (HIF2A), a key hypoxia-sensing regulator, are associated with erythrocytosis, thrombosis, and vascular complications that account for morbidity and mortality of patients. We demonstrated that the vascular pathology...

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Bibliographic Details
Main Authors: Xin Yi Chan, Eugenia Volkova, Joon Eoh, Rebecca Black, Lilly Fang, Rayyan Gorashi, Jihyun Song, Jing Wang, Morgan B. Elliott, Sebastian F. Barreto-Ortiz, James Chen, Brian L. Lin, Lakshmi Santhanam, Linzhao Cheng, Frank S. Lee, Josef T. Prchal, Sharon Gerecht
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:iScience
Subjects:
Pathophysiology
Biophysics
Biomechanics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221002145

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http://www.sciencedirect.com/science/article/pii/S2589004221002145

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