Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Experimental Mutations in Superoxide Dismutase 1 Provide Insight into Potential Mechanisms Involved in Aberrant Aggregation in Familial Amyotrophic Lateral Sclerosis

Mutations in more than 80 different positions in superoxide dismutase 1 (SOD1) have been associated with amyotrophic lateral sclerosis (fALS). There is substantial evidence that a common consequence of these mutations is to induce the protein to misfold and aggregate. How these mutations perturb nat...

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Bibliographic Details
Main Authors: Anthony M. Crown, Brittany L. Roberts, Keith Crosby, Hilda Brown, Jacob I. Ayers, P. John Hart, David R. Borchelt
Format: Article
Language:English
Published: Oxford University Press 2019-03-01
Series:G3: Genes, Genomes, Genetics
Subjects:
mutagenesis
structure
protein aggregation
cell models
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200787

Internet

http://g3journal.org/lookup/doi/10.1534/g3.118.200787

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