Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects

This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (<i>Curcuma longa</i>) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo d...

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Main Authors: Aleksandra Zielińska, Henrique Alves, Vânia Marques, Alessandra Durazzo, Massimo Lucarini, Thais F. Alves, Margreet Morsink, Niels Willemen, Piotr Eder, Marco V. Chaud, Patricia Severino, Antonello Santini, Eliana B. Souto
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Medicina
Subjects:
curcumin
nanopharmaceutics
nanoparticles
cancer
health properties
Online Access:https://www.mdpi.com/1010-660X/56/7/336
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spelling doaj-1f685ccc302c4a92b9b494de3fbfc1d92020-11-25T03:27:18ZengMDPI AGMedicina1010-660X2020-07-015633633610.3390/medicina56070336Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health EffectsAleksandra Zielińska0Henrique Alves1Vânia Marques2Alessandra Durazzo3Massimo Lucarini4Thais F. Alves5Margreet Morsink6Niels Willemen7Piotr Eder8Marco V. Chaud9Patricia Severino10Antonello Santini11Eliana B. Souto12Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, ItalyCREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, ItalyLaboratory of Biomaterials and Nanotechnology, University of Sorocaba-UNISO, Sorocaba, São Paulo 18023-000, BrazilCenter for Biomedical Engineering, Department of Medicine, Brigham and Women& Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USACenter for Biomedical Engineering, Department of Medicine, Brigham and Women& Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USADepartment of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznań, PolandLaboratory of Biomaterials and Nanotechnology, University of Sorocaba-UNISO, Sorocaba, São Paulo 18023-000, BrazilCenter for Biomedical Engineering, Department of Medicine, Brigham and Women& Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USADepartment of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131 Napoli, ItalyDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalThis review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (<i>Curcuma longa</i>) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.https://www.mdpi.com/1010-660X/56/7/336curcuminnanopharmaceuticsnanoparticlescancerhealth properties
collection DOAJ
language English
format Article
sources DOAJ
author Aleksandra Zielińska
Henrique Alves
Vânia Marques
Alessandra Durazzo
Massimo Lucarini
Thais F. Alves
Margreet Morsink
Niels Willemen
Piotr Eder
Marco V. Chaud
Patricia Severino
Antonello Santini
Eliana B. Souto
spellingShingle Aleksandra Zielińska
Henrique Alves
Vânia Marques
Alessandra Durazzo
Massimo Lucarini
Thais F. Alves
Margreet Morsink
Niels Willemen
Piotr Eder
Marco V. Chaud
Patricia Severino
Antonello Santini
Eliana B. Souto
Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects
Medicina
curcumin
nanopharmaceutics
nanoparticles
cancer
health properties
author_facet Aleksandra Zielińska
Henrique Alves
Vânia Marques
Alessandra Durazzo
Massimo Lucarini
Thais F. Alves
Margreet Morsink
Niels Willemen
Piotr Eder
Marco V. Chaud
Patricia Severino
Antonello Santini
Eliana B. Souto
author_sort Aleksandra Zielińska
title Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects
title_short Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects
title_full Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects
title_fullStr Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects
title_full_unstemmed Properties, Extraction Methods, and Delivery Systems for Curcumin as a Natural Source of Beneficial Health Effects
title_sort properties, extraction methods, and delivery systems for curcumin as a natural source of beneficial health effects
publisher MDPI AG
series Medicina
issn 1010-660X
publishDate 2020-07-01
description This review discusses the impact of curcumin—an aromatic phytoextract from the turmeric (<i>Curcuma longa</i>) rhizome—as an effective therapeutic agent. Despite all of the beneficial health properties ensured by curcumin application, its pharmacological efficacy is compromised in vivo due to poor aqueous solubility, high metabolism, and rapid excretion that may result in poor systemic bioavailability. To overcome these problems, novel nanosystems have been proposed to enhance its bioavailability and bioactivity by reducing the particle size, the modification of surfaces, and the encapsulation efficiency of curcumin with different nanocarriers. The solutions based on nanotechnology can improve the perspective for medical patients with serious illnesses. In this review, we discuss commonly used curcumin-loaded bio-based nanoparticles that should be implemented for overcoming the innate constraints of this natural ingredient. Furthermore, the associated challenges regarding the potential applications in combination therapies are discussed as well.
topic curcumin
nanopharmaceutics
nanoparticles
cancer
health properties
url https://www.mdpi.com/1010-660X/56/7/336
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