Kinetic Transition in Amyloid Assembly as a Screening Assay for Oligomer-Selective Dyes

Kinetic Transition in Amyloid Assembly as a Screening Assay for Oligomer-Selective Dyes

Assembly of amyloid fibrils and small globular oligomers is associated with a significant number of human disorders that include Alzheimer’s disease, senile systemic amyloidosis, and type II diabetes. Recent findings implicate small amyloid oligomers as the dominant aggregate species media...

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Bibliographic Details
Main Authors: Jeremy Barton, D. Sebastian Arias, Chamani Niyangoda, Gustavo Borjas, Nathan Le, Saefallah Mohamed, Martin Muschol
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
oligomer formation
amyloidosis
assembly pathway
dye fluorescence
thioflavin t
Online Access:https://www.mdpi.com/2218-273X/9/10/539

Internet

https://www.mdpi.com/2218-273X/9/10/539

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