Sex differences in cerebellar synaptic transmission and sex-specific responses to autism-linked Gabrb3 mutations in mice

Sex differences in cerebellar synaptic transmission and sex-specific responses to autism-linked Gabrb3 mutations in mice

Neurons of the cerebellar nuclei (CbN) transmit cerebellar signals to premotor areas. The cerebellum expresses several autism-linked genes, including GABRB3, which encodes GABAA receptor β3 subunits and is among the maternal alleles deleted in Angelman syndrome. We tested how this Gabrb3 m-/p+ mutat...

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Bibliographic Details
Main Authors: Audrey A Mercer, Kristin J Palarz, Nino Tabatadze, Catherine S Woolley, Indira M Raman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-04-01
Series:eLife
Subjects:
metabotropic glutamate receptor
cerebellar nuclei
Purkinje
sexual dimorphism
Angelman syndrome
group I mGluR
Online Access:https://elifesciences.org/articles/07596

Internet

https://elifesciences.org/articles/07596

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