Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

The role of macroautophagy in neuronal processes mediating brain maintenance remains enigmatic. Authors show here that impairing autophagy within the major learning related brain center of Drosophila, and not other regions, triggered a form of presynaptic metaplasticity that was invariably connected...

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Bibliographic Details
Main Authors: Anuradha Bhukel, Christine Brigitte Beuschel, Marta Maglione, Martin Lehmann, Gabor Juhász, Frank Madeo, Stephan J. Sigrist
Format: Article
Language:English
Published: Nature Publishing Group 2019-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09262-2