Regulation of hypoxia-inducible factor-1α (HIF-1α) expression by interleukin-1β (IL-1 β), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes

Regulation of hypoxia-inducible factor-1α (HIF-1α) expression by interleukin-1β (IL-1 β), insulin-like growth factors I (IGF-I) and II (IGF-II) in human osteoarthritic chondrocytes

OBJECTIVE: Hypoxia-inducible factor 1 alpha regulates genes related to cellular survival under hypoxia. This factor is present in osteroarthritic chondrocytes, and cytokines, such as interleukin-1 beta, participate in the pathogenesis of osteoarthritis, thereby increasing the activities of proteolyt...

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Bibliographic Details
Main Authors: Angelica Rossi Sartori-Cintra, Cristiane Sampaio de Mara, Danielle L Argolo, Ibsen Bellini Coimbra
Format: Article
Language:English
Published: Faculdade de Medicina / USP 2012-01-01
Series:Clinics
Subjects:
HIF-1α
Chondrocytes
Phosphatidylinositol-3-kinase (PI-3K), Cytokines
IL-1β
Growth factors
IGF-I, IGF-II, Osteoarthritis
Articular cartilage
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000100006

Internet

http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322012000100006

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