Induction of Heat Shock Protein 70 Ameliorates Ultraviolet-Induced Photokeratitis in Mice

Induction of Heat Shock Protein 70 Ameliorates Ultraviolet-Induced Photokeratitis in Mice

Acute ultraviolet (UV) B exposure causes photokeratitis and induces apoptosis in corneal cells. Geranylgeranylacetone (GGA) is an acyclic polyisoprenoid that induces expression of heat shock protein (HSP)70, a soluble intracellular chaperone protein expressed in various tissues, protecting cells aga...

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Bibliographic Details
Main Authors: Yukihiro Horie, Akira Nakai, Shigeaki Ohno, Nobuyoshi Kitaichi, Kousuke Noda, Satoru Kase, Anton Lennikov, Susumu Ishida
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:International Journal of Molecular Sciences
Subjects:
GGA
geranylgeranylacetone
HSP
HSP70
UVB
keratitis
cornea
apoptosis
Online Access:http://www.mdpi.com/1422-0067/14/1/2175

Internet

http://www.mdpi.com/1422-0067/14/1/2175

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