The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice

The hydrogen-peroxide producing NADPH oxidase 4 does not limit neointima development after vascular injury in mice

Objective: The NADPH oxidase Nox4 is an important source of H2O2. Nox4-derived H2O2 limits vascular inflammation and promotes smooth muscle differentiation. On this basis, the role of Nox4 for restenosis development was determined in the mouse carotid artery injury model. Methods and results: Geneti...

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Bibliographic Details
Main Authors: Giulia K. Buchmann, Christoph Schürmann, Manuela Spaeth, Wesley Abplanalp, Lukas Tombor, David John, Timothy Warwick, Flávia Rezende, Andreas Weigert, Ajay M. Shah, Martin-Leo Hansmann, Norbert Weissmann, Stefanie Dimmeler, Katrin Schröder, Ralf P. Brandes
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Redox Biology
Subjects:
NADPH oxidase
Nox4
Restenosis
Reactive oxygen species
Carotid injury
Single-cell RNA sequencing
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002093

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http://www.sciencedirect.com/science/article/pii/S2213231721002093

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