Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?

Interaction between host genes and Mycobacterium tuberculosis lineage can affect tuberculosis severity: Evidence for coevolution?

Genetic studies of both the human host and Mycobacterium tuberculosis (MTB) demonstrate independent association with tuberculosis (TB) risk. However, neither explains a large portion of disease risk or severity. Based on studies in other infectious diseases and animal models of TB, we hypothesized t...

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Bibliographic Details
Main Authors: Michael L McHenry, Jacquelaine Bartlett, Robert P Igo, Eddie M Wampande, Penelope Benchek, Harriet Mayanja-Kizza, Kyle Fluegge, Noemi B Hall, Sebastien Gagneux, Sarah A Tishkoff, Christian Wejse, Giorgio Sirugo, W Henry Boom, Moses Joloba, Scott M Williams, Catherine M Stein
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-04-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1008728

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https://doi.org/10.1371/journal.pgen.1008728

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