In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways

In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways

Malignant melanoma is the most lethal form of skin cancer, with a high propensity to metastasize to the brain. More than 60% of melanomas have the BRAFV600E mutation, which activates the mitogen-activated protein kinase (MAPK) pathway [1]. In addition, increased PI3K (phosphoinositide 3-kinase) pat...

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Bibliographic Details
Main Authors: Inderjit Daphu, Sindre Horn, Daniel Stieber, Jobin K. Varughese, Endy Spriet, Hege Avsnes Dale, Kai Ove Skaftnesmo, Rolf Bjerkvig, Frits Thorsen
Format: Article
Language:English
Published: MDPI AG 2014-05-01
Series:International Journal of Molecular Sciences
Subjects:
melanoma brain metastasis
BRAF
PTEN
PI3K (phosphoinositide 3-kinase)
MAPK (mitogen-activated protein kinase)
mTOR
temsirolimus
vemurafenib
Online Access:http://www.mdpi.com/1422-0067/15/5/8773

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http://www.mdpi.com/1422-0067/15/5/8773

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