Pharmacological Modulation of Blood–Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions

Pharmacological Modulation of Blood–Brain Barrier Permeability by Kinin Analogs in Normal and Pathologic Conditions

The blood–brain barrier (BBB) is a major obstacle to the development of effective diagnostics and therapeutics for brain cancers and other central nervous system diseases. Peptide agonist analogs of kinin B1 and B2 receptors, acting as BBB permeabilizers, have been utilized to overcome this barrier....

Full description

Bibliographic Details
Main Authors: Dina Sikpa, Lisa Whittingstall, Martin Savard, Réjean Lebel, Jérôme Côté, Stephen McManus, Sylvain Chemtob, David Fortin, Martin Lepage, Fernand Gobeil
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceuticals
Subjects:
kinin analogs
G protein-coupled receptors
blood–brain barrier permeability
chemotherapy
radiotherapy
CNS diseases
Online Access:https://www.mdpi.com/1424-8247/13/10/279

Internet

https://www.mdpi.com/1424-8247/13/10/279

Similar Items