Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors

Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors

The regulatory function of α1B-adrenoceptors in mammalian heart homeostasis is controversial. The objective of the present study was to characterize the expression/activity of key proteins implicated in cardiac calcium handling (Na+/K+-ATPase and Ca2+-ATPases) and growth (ERK1/2, JNK1/2 and p38) in...

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Bibliographic Details
Main Authors: F. Barreto, D.C. Rezende, C.B.V. Scaramello, C.L.M. Silva, V.M.N. Cunha, A. Caricati-Neto, A. Jurkiewicz, F. Noël, L.E.M. Quintas
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2010-05-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
α1B-adrenoceptors
Ca2+-ATPases
Cardiac hypertrophy
Na+/K+-ATPase
Mitogen-activated protein kinases
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500012&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000500012&lng=en&tlng=en

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