Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner

Oligomeric amyloid-beta induces MAPK-mediated activation of brain cytosolic and calcium-independent phospholipase A2 in a spatial-specific manner

Abstract Alzheimer’s disease (AD) is histopathologically characterized by the build-up of fibrillar amyloid beta (Aβ) in the form of amyloid plaques and the development of intraneuronal neurofibrillary tangles consisting of aggregated hyperphosphorylated Tau. Although amyloid fibrils were originally...

Full description

Bibliographic Details
Main Authors: Juan Pablo Palavicini, Chunyan Wang, Linyuan Chen, Kristen Hosang, Jianing Wang, Takami Tomiyama, Hiroshi Mori, Xianlin Han
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Acta Neuropathologica Communications
Subjects:
Alzheimer’s disease
Amyloid-beta
Fatty acid
Lysophospholipid
Phospholipase A2
Oxidative stress
Online Access:http://link.springer.com/article/10.1186/s40478-017-0460-6

Internet

http://link.springer.com/article/10.1186/s40478-017-0460-6

Similar Items