Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis

Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-374a Decreases Inflammation and Maintains Intestinal Barrier Function in Colitis

Activation of phosphatase and tensin homolog (PTEN) is known to induce cell apoptosis. MicroRNA-374a (miR-374a), which can suppress PTEN expression, has been found abnormally expressed in inflammatory bowel disease (IBD). Fortunellin is a citrus flavonoid that is a potential anti-inflammation agent...

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Bibliographic Details
Main Authors: Yongjian Xiong, Juanjuan Qiu, Changyi Li, Yang Qiu, Li Guo, Yuejian Liu, Jiajia Wan, Yuchun Li, Guokai Wu, Liang Wang, Zijuan Zhou, Jianyi Dong, Chunhua Du, Dapeng Chen, Huishu Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
fortunellin
microRNA-374a
colitis
epithelium
inflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00083/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00083/full

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