An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

An engineered IL-2 reprogrammed for anti-tumor therapy using a semi-synthetic organism

The use of synthetic organisms could provide opportunities for discovery and advanced manufacturing of medical drugs. Here the authors use a semi-synthetic organism with an expanded genetic code to generate site-specific chemical modifications in human IL-2.

Bibliographic Details
Main Authors: Jerod L. Ptacin, Carolina E. Caffaro, Lina Ma, Kristine M. San Jose Gall, Hans R. Aerni, Nicole V. Acuff, Rob W. Herman, Yelena Pavlova, Michael J. Pena, David B. Chen, Lilia K. Koriazova, Laura K. Shawver, Ingrid B. Joseph, Marcos E. Milla
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24987-9

Internet

https://doi.org/10.1038/s41467-021-24987-9

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