A Stochastic Multiscale Model That Explains the Segregation of Axonal Microtubules and Neurofilaments in Neurological Diseases.

The organization of the axonal cytoskeleton is a key determinant of the normal function of an axon, which is a long thin projection of a neuron. Under normal conditions two axonal cytoskeletal polymers, microtubules and neurofilaments, align longitudinally in axons and are interspersed in axonal cro...

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Bibliographic Details
Main Authors: Chuan Xue, Blerta Shtylla, Anthony Brown
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-08-01
Series:PLoS Computational Biology
Online Access:http://europepmc.org/articles/PMC4540448?pdf=render