Localization and role of NPC1L1 in cholesterol absorption in human intestine

Localization and role of NPC1L1 in cholesterol absorption in human intestine

Recent studies have documented the presence of Niemann-Pick C1-Like 1 (NPC1L1) in the small intestine and its capacity to transport cholesterol in mice and rats. The current investigation was undertaken to explore the localization and function of NPC1L1 in human enterocytes. Cell fractionation exper...

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Bibliographic Details
Main Authors: Alain Théophile Sané, Daniel Sinnett, Edgard Delvin, Moise Bendayan, Valérie Marcil, Daniel Ménard, Jean-François Beaulieu, Emile Levy
Format: Article
Language:English
Published: Elsevier 2006-10-01
Series:Journal of Lipid Research
Subjects:
enterocyte
3-hydroxy-3-methylglutaryl-coenzyme A reductase
acyl-coenzyme A:cholesterol acyltransferase
scavenger receptor class B type I
sterol-regulatory element binding protein
cluster determinant 36
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520433991

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http://www.sciencedirect.com/science/article/pii/S0022227520433991

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