Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension.

Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension.

Coagulation factor VIII (FVIII) deficiency leads to haemophilia A. Conversely, elevated plasma levels are a strong predictor of recurrent venous thromboemboli and pulmonary hypertension phenotypes in which in situ thromboses are implicated. Extrahepatic sources of plasma FVIII are implicated, but ha...

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Bibliographic Details
Main Authors: Claire L Shovlin, Gillian Angus, Richard A Manning, Grace N Okoli, Fatima S Govani, Kay Elderfield, Graeme M Birdsey, Inês G Mollet, Michael A Laffan, Francesco A Mauri
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2823490?pdf=render

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http://europepmc.org/articles/PMC2823490?pdf=render

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