Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate

Regulation of Muscle Pyruvate Dehydrogenase Complex in Insulin Resistance: Effects of Exercise and Dichloroacetate

Since the mitochondrial pyruvate dehydrogenase complex (PDC) controls the rate of carbohydrate oxidation, impairment of PDC activity mediated by high-fat intake has been advocated as a causative factor for the skeletal muscle insulin resistance, metabolic syndrome, and the onset of type 2 diabetes (...

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Bibliographic Details
Main Author: Dumitru Constantin-Teodosiu
Format: Article
Language:English
Published: Korean Diabetes Association 2013-10-01
Series:Diabetes & Metabolism Journal
Subjects:
Carnitine
Diabetes mellitus, type 2
Dichloroacetate
Diet, high-fat
Exercise
Glucose disposal
Inflammation
Peroxisome proliferator-activated receptors
Statins
Online Access:http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-301.pdf

Internet

http://e-dmj.org/Synapse/Data/PDFData/2004DMJ/dmj-37-301.pdf

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