Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.

Erythroid-Specific Expression of LIN28A Is Sufficient for Robust Gamma-Globin Gene and Protein Expression in Adult Erythroblasts.

Increasing fetal hemoglobin (HbF) levels in adult humans remains an active area in hematologic research. Here we explored erythroid-specific LIN28A expression for its effect in regulating gamma-globin gene expression and HbF levels in cultured adult erythroblasts. For this purpose, lentiviral transd...

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Bibliographic Details
Main Authors: Y Terry Lee, Jaira F de Vasconcellos, Colleen Byrnes, Megha Kaushal, Antoinette Rabel, Laxminath Tumburu, Joshua M Allwardt, Jeffery L Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4684222?pdf=render

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http://europepmc.org/articles/PMC4684222?pdf=render

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