A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole

A novel ABCG-like transporter of Trypanosoma cruzi is involved in natural resistance to benznidazole

Benznidazole (BZ) is one of the two drugs used for Chagas disease treatment. Nevertheless therapeutic failures of BZ have been reported, which were mostly attributed to variable drug susceptibility among Trypanosoma cruzi strains. ATP-binding cassette (ABC) transporters are involved in a variety of...

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Bibliographic Details
Main Authors: Bianca Zingales, Rafael Gomes Aquino Araujo, Margoth Moreno, Jaques Franco, Pedro Henrique Nascimento Aguiar, Solange Lessa Nunes, Marcelo Nunes Silva, Susan Ienne, Carlos Renato Machado, Adeilton Brandão
Format: Article
Language:English
Published: Instituto Oswaldo Cruz, Ministério da Saúde 2015-05-01
Series:Memórias do Instituto Oswaldo Cruz.
Subjects:
Chagas disease
benznidazole resistance
ABCG transporter
T. cruzi
strains
transcript abundance
single nucleotide polymorphisms
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000300433&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000300433&lng=en&tlng=en

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