Synthesis and Biological Evaluation of Thio-Derivatives of 2-Hydroxy-1,4-Naphthoquinone (Lawsone) as Novel Antiplatelet Agents

Synthesis and Biological Evaluation of Thio-Derivatives of 2-Hydroxy-1,4-Naphthoquinone (Lawsone) as Novel Antiplatelet Agents

We designed and synthesized in water, using conventional heating and microwave irradiation, new thio-derivatives of 2-hydroxy-1,4-naphthoquinone, a naturally occurring pigment known as lawsone or hennotannic acid, thus improving their antiplatelet activity with relevance to their potential future us...

Full description

Bibliographic Details
Main Authors: Matías Monroy-Cárdenas, Diego Méndez, Andrés Trostchansky, Maximiliano Martínez-Cifuentes, Ramiro Araya-Maturana, Eduardo Fuentes
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Chemistry
Subjects:
lawsone
naphthoquinone
small compounds
platelet
thrombosis
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2020.00533/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2020.00533/full

Similar Items