Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors

Bis-Quinolinium Cyclophane Blockers of SK Potassium Channels Are Antagonists of M3 Muscarinic Acetylcholine Receptors

Dequalinium is used as an antimicrobial compound for oral health and other microbial infections. Derivatives of dequalinium, the bis-quinolinium cyclophanes UCL 1684 and UCL 1848, are high affinity SK potassium channel antagonists. Here we investigated these compounds as M3 muscarinic receptor (mACH...

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Bibliographic Details
Main Authors: Vladislav Bugay, Derek J. Wallace, Bin Wang, Irving Salinas, Adriana Paola Chapparo, Hudson Ryan Smith, Peter Herbert Dube, Edward G. Brooks, Kelly Ann Berg, Robert Brenner
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
muscarinic receptor
SK channel
dequalinium
UCL 1684
airway smooth muscle
contraction
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.552211/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.552211/full

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