Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

HTRA2, a serine protease in the intermembrane space, has important functions in mitochondrial stress signaling while its abnormal activity may contribute to the development of Parkinson's disease. Mice with a missense or null mutation of Htra2 fail to thrive, suffer striatal neuronal loss, and...

Full description

Bibliographic Details
Main Authors: Victoria L Patterson, Alfred J Zullo, Claire Koenig, Sean Stoessel, Hakryul Jo, Xinran Liu, Jinah Han, Murim Choi, Andrew T DeWan, Jean-Leon Thomas, Chia-Yi Kuan, Josephine Hoh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4274161?pdf=render

Internet

http://europepmc.org/articles/PMC4274161?pdf=render

Similar Items