Temporal profiling of Kv1.3 channel expression in brain mononuclear phagocytes following ischemic stroke

Temporal profiling of Kv1.3 channel expression in brain mononuclear phagocytes following ischemic stroke

Abstract Background Microglia and CNS-infiltrating monocytes/macrophages (CNS-MPs) perform pro-inflammatory and protective anti-inflammatory functions following ischemic stroke. Selective inhibition of pro-inflammatory responses can be achieved by Kv1.3 channel blockade, resulting in a lower infarct...

Full description

Bibliographic Details
Main Authors: Tianwen Gao, Syed Ali Raza, Supriya Ramesha, Ngozi V. Nwabueze, Amelia J. Tomkins, Lihong Cheng, Hailian Xiao, Manuel Yepes, Srikant Rangaraju
Format: Article
Language:English
Published: BMC 2019-06-01
Series:Journal of Neuroinflammation
Subjects:
Ischemic stroke
Kv1.3
Macrophage
Microglia
Middle cerebral artery occlusion
Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-019-1510-8

Internet

http://link.springer.com/article/10.1186/s12974-019-1510-8

Similar Items